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"STEM CELL REVOLUTION"

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FAQ

Our Technology

Park Avenue Stem Cell uses adipose derived stem cells for deployment & clinical research. Early stem cell research has traditionally been associated with the controversial use of embryonic stem cells. The new focus is on non-embryonic adult mesenchymal stem cells which are found in a person’s own blood, and fat.

A recent technological breakthrough enables us to now use adipose (fat) derived stem cells. Autologous stem cells from a person’s own fat are easy to harvest safely under local anesthesia and are abundant in quantities up to 2500 times those seen in bone marrow.

Clinical success and favorable outcomes appear to be related directly to the quantity of stem cells deployed. Once these adipose derived stem cells are administered back in to the patient, they have the potential to repair human tissue by forming new cells of mesenchymal origin, such as cartilage, bone, ligaments, tendons, nerve, fat, muscle, blood vessels, and certain internal organs. Stem cells’ ability to form cartilage and bone makes them potentially highly effective in the treatment of degenerative orthopedic conditions. Their ability to form new blood vessels and smooth muscle makes them potentially very useful in the treatment of peyronies disease and impotence. Stem cells are used extensively in Europe and Asia to treat these conditions.

We have anecdotal and experimental evidence that stem cell therapy is effective in healing and regeneration. Stem cells seek out damaged tissues in order to repair the body naturally. The literature and internet is full of successful testimonials but we are still awaiting definitive studies demonstrating efficacy of stem cell therapy. Such data may take five or ten years to accumulate. In an effort to provide relief for patients suffering from certain degenerative diseases that have been resistant to common modalities of treatment, we are initiating pilot studies as experimental tests of treatment effectiveness with very high numbers of adipose derived stem cells obtained from fat. Adipose fat is an abundant and reliable source of stem cells.

Park Avenue Stem Cell cell harvesting and isolation techniques are based on technology from Korea. This new technological breakthrough allows patients to safely receive their own autologous stem cells in extremely large quantities. Our treatments and research are patient funded and we have endeavored successfully to make it affordable. All of our sterile procedures are non-invasive and done under local anesthesia. Patients who are looking for non-surgical alternatives to their degenerative disorders can participate in our trials by filling out our treatment application to determine if they are candidates. Park Avenue Stem Cell is proud to be state of the art in the new field of Regenerative Medicine.

Cell Banking

Cryo-preservation and banking of adipose derived stem cells is possible and can be performed at the same time as your SVF deployment procedure. Cells On Ice™ is the company that handles this process in collaboration with their technology partner American CryoStem (ACS). Autologous lipo-aspirate can be frozen as fat or as SVF. SVF can be frozen for repeated deployments and in the near future (pending regulatory approval) expanded into nearly unlimited quantities of autologous stem cells. This will provide patients with their own personal stem cell line that could be used “on demand” for everything from treating stroke, heart attack, serious accident, or even cancer therapy at any time in their life. The Cells On Ice™ program is also vital since many of the conditions we treat such as neuro-degenerative disorders and auto-immune conditions often require repeat deployments and using banked autologous cells allows this to be done in a convenient and cost effective manner. For more information on banking your own cells call 855-204-0302.

What types of specialties are represented at Park Avenue Stem Cell?

A wide range of medical specialties is represented including urology, cosmetic surgery, ear, nose, & throat, sports medicine, functional medicine, orthopedics, internal medicine and cardiology to name a few. Our Network continues to grow and add experts from various other fields. Park Avenue Stem Cell is the first multispecialty stem cell center in the United States.

Why does Park Avenue Stem Cell take a multispecialty treatment approach to regenerative medicine?

Patients suffer from many varieties of degenerative illnesses. There may be conditions associated with nearly all aspects of the body. Board certified specialists are ideal to evaluate, recommend and/or treat, and subsequently follow your progress. Together, through the PASC, we work to coordinate and provide therapy – mainly with your own stem cells, but also through other avenues of regenerative medicine. This could include hormone replacement therapy or other appropriate recommendations.

For example, if you have a knee problem, Our staff at PASC may collaborate with other affiliates with specific expertise in treating certain joints. Also, you might be recommended for evaluation for hormone replacement therapy or an exercise program should such be considered optimal. Nonetheless, we believe stem cell therapy to be the likely foundation for regenerative treatment. It should also be noted, that all treatments are currently in the investigational stage. While we recognize our patients are seeking improvement in their condition through stem cell therapy, each treatment is part of an ongoing investigation to establish optimal parameters for treatment, to evaluate for effectiveness and for any adverse effects. It is essential that patients understand they are participating in these investigational (research) analyses. Once sufficient information is appropriately documented and statistically significant, then data (validated by an Institutional Review Board) may be presented to the FDA for consideration of making an actual claim.

How does Park Avenue Stem Cell control sterility in the processing of the stem cells?

Stem cells are harvested under sterile conditions using a special “closed system” technology so that the cells never come into contact with the environment throughout the entire process from removal to deployment. Sterile technique and antibiotics are also used to prevent infection.

Are any biological agents added to the stem cells such as medications or mixtures containing Plasma Enriched Platelets?

Our adipose derived stem cell harvesting and isolation technique yields extremely high numbers of stem cells. In reviewing outcomes data, treatment cell numbers appear to correlate with treatment success. Our cells are actually in a type of “soup” called Stromal Vascular Fraction SVF which is stem cells bathed in a rich mixture of natural growth factors (Not the same as human growth factor hormone which is only one type of growth factor). Some types of orthopedic and urologic diseases appear to respond better to stem cells that are super enriched with growth factors created by administering Platelet Rich Plasma to the patient. Autologous Platelet Rich Plasma is derived from a patient’s own blood drawn at the time of deployment. At PASC we do not add any foreign substances or medications to the stem cells.

What are the tools of regenerative medicine?

Traditionally, we have used various medications and hormones to limit disease and help the body repair itself. For example, hormone replacement therapy has, in many cases, shown the ability to more optimally help the immune system and thus help us repair diseased or injured tissues. Genetic research is an evolving area where we will eventually learn and utilize more ways of specifically dealing with gene defects causing degenerative disease. Stem cell therapy has already shown considerable promise in treating many degenerative conditions. Stem cells communicate with our tissues and with each other through a complex system of protein signaling molecules called cytokines or “growth factors.” There are thousands of growth factors and some FDA approved and clinically available such as AQ topical growth factors (see store) that are useful for a number of cosmetic and therapeutic purposes. The science of using growth factors with stem cells is evolving and represents the next main area of growth in regenerative medicine.

Why does Park Avenue Stem Cell use liposuction fat rather than bone marrow as a source of stem cells?

Bone marrow sampling (a somewhat uncomfortable procedure) yields approximately 5,000 – 60,000 cells that are then cultured over several days to perhaps a few million cells prior to deployment (injection into the patient). Recent advances in stem cell science have made it possible to obtain high numbers of very excellent quality multi-potent (able to form numerous other tissues) cells from a person’s own liposuction fat. PASC uses technology acquired from Asia to process this fat to yield approximately five hundred thousand to one million stem cells per cc of fat, and therefore, it is possible to obtain as many as 10 to 40 million cells from a single treatment. These adipose derived stem cells can form many different types of cells when deployed properly including bone, cartilage, tendon (connective tissue), muscle, blood vessels, nerve tissue and others

What is a Stem Cell?

A stem cell is basically any cell that can replicate and differentiate. This means the cell can not only multiply, it can turn into different types of tissues. There are different kinds of stem cells. Most people are familiar with or have heard the term “embryonic stem cell.” These are cells from the embryonic stage that have yet to differentiate – as such, they can change into any body part at all. These are then called “pluri-potential” cells. Because they are taken from unborn or unwanted embryos, there has been considerable controversy surrounding their use. Also, while they have been used in some areas of medicine – particularly, outside the United States – they have also been associated with occasional tumor (teratoma) formations. There is work being conducted by several companies to isolate particular lines of embryonic stem cells for future use.

Another kind of stem cell is the “adult stem cell.” This is a stem cell that already resides in one’s body within different tissues. In recent times, much work has been done isolating bone-marrow derived stem cells. These are also known as “mesenchymal stem cells” because they come from the mesodermal section of your body. They can differentiate into bone and cartilage, and probably all other mesodermal elements, such as fat, connective tissue, blood vessels, muscle and nerve tissue. Bone marrow stem cells can be extracted and because they are low in numbers, they are usually cultured in order to multiply their numbers for future use. As it turns out, fat is also loaded with mesenchymal stem cells. In fact, it has hundreds if not thousands of times more stem cells compared to bone marrow. Today, we actually have tools that allow us to separate the stem cells from fat. Because most people have adequate fat supplies and the numbers of stem cells are so great, there is no need to culture the cells over a period of days and they can be used right away.

How do Adult Stem Cells Heal?

These adult stem cells are known as “progenitor” cells. This means they remain dormant (do nothing) unless they witness some level of tissue injury. It’s the tissue injury that turns them on. So, when a person has a degenerative type problem, the stem cells tend to go to that area of need and stimulate the healing process. We’re still not sure if they simply change into the type of injured tissue needed for repair or if they send out signals that induces the repair by some other mechanism. Suffice it to say that there are multiple animal models and a plethora of human evidence that indicates these are significant reparative cells.

Non Embryonic Adult Stem Cells

Adult (NonEmbryonic) Mesenchymal Stem Cells are undifferentiated cells that have the ability to replace dying cells and regenerate damaged tissue. These special cells seek out areas of injury, disease and destruction where they are capable of regenerating healthy cells and enabling a person’s natural healing processes to be accelerated. As we gain a deeper understanding of their medical function and apply this knowledge, we are realizing their enormous therapeutic potential to help the body heal itself. Adult stem cells have been used for a variety of medical treatments to repair and regenerate acute and chronicially damaged tissues in humans and animals. The use of stem cells is not FDA approved for the treatment of any specific disease in the United States at this time and their use is therefore investigational. Many reputable international centers have been using stem cell therapy to treat various chronic degenerative conditions as diverse as severe neurologic diseases, renal failure, erectile dysfunction, degenerative orthopedic problems, and even cardiac and pulmonary diseases to name a few. Adult stem cells appear to be particularly effective at repairing cartilage in degenerated joints.

What Diseases & Problems Can Be Treated?

This will depend on the type of degenerative condition you have. A specialist will evaluate you and discuss whether you’re a potential candidate for stem cell therapy. If after you’ve been recommended for treatment, had an opportunity to understand the potential risks and benefits, and decided on your own that you would like to explore this avenue of treatment, then you can be considered for treatment. Of course, even though it’s a minimally invasive procedure, you will still need to be medically cleared for the procedure.

Why do patients request stem cell treatment?

Many have been told that they require surgery or other risky treatments for their ailments and are looking for non-invasive options. Some have heard about the compelling testimonials about stem cells in the literature and on various websites. Many have read about the results of stem cell treatments in animal models and in humans. PASC does not believe in claims or testimonials since our work is still investigational but we are a resource for patients who need access to regenerative care.PASC gives a choice to those informed patients who seek modern regenerative therapy but desire convenience, quality and affordability. PASC fills a need for those patients who have been told that they have to travel to different countries and pay as much as twenty to one hundred thousand dollars for stem cell treatments off shore.

Are there reports of autologous adipose derived adult mesenchymal stem cells harming any humans or animals?

We know of no documented cases personally or in the literature where serious harm has resulted. All of our patients will be entered into a database to follow and report any adverse reactions. This information is vital to the development of stem cell science. There have been a few reports of serious complications from overseas and these are being thoroughly evaluated by epidemiologists to ascertain the facts. The International Stem Cell Society registry has over 1,000 cases currently registered and only 2% of the treatments were associated with any complications, none of which were considered “serious adverse events.”

Can stem cells treat cancer?

Stem cells have played an important role in cancer therapy for five decades. Hematopoetic stem cells (similar to mesenchymal stem cells and also found in stromal vascular fraction) have been used to restore bone marrow and replace blood cell lines after planned ablation of a cancer patient’s bone marrow. This is known as a “stem cell transplant” and is associated with significant risk to cancer patients. Of course this is different than a regenerative therapy using stem cells to replace or repair damaged tissue. Having said that, new advances in cancer therapy have exploited stem cell property known as “TROPISM” which is the ability of stem cells to target tumors. This property has been used to help carry cancer killing agents deep into the cancer where the body’s immune system cannot always operate effectively. Park Avenue Stem Cell is involved in cutting edge clinical trials using stem cells to carry cancer-killing viruses deep into cancer tissue that has not responded to conventional therapy. For more information on this study, call 800-231-0407.

Can stem cells cause cancer?

Adult mesenchymal stem cells are not known to cause cancer. Some patients have heard of stories of cancer caused by stem cells, but these are probably related to the use of embryonic cells (Not Adult Mesenchymal Cells). These embryonic tumors known as teratomas are rare but possible occurrences when embryonic cells are used.

What about patients with known cancers?

Stem cell therapy is thought to be safe and not affect dormant cancers. If someone has had cancer that was treated and responded successfully, there is no reason to withhold stem cell deployment. In most cases, stem cells should not be used in patients with known active cancer outside of an active protocol (see “Can stem cells treat cancer”).

Is Our Procedure FDA Approved?

NO. However, Park Avenue Stem Cell’s surgical procedures fall under the category of physician’s practice of medicine, wherein the physician and patient are free to consider their chosen course of treatment. The FDA does have guidelines about treatment and manipulation of a patient’s own tissues. At PASC we meet these guidelines by providing same day treatment with the patient’s own cells that undergo no manipulation and are inserted during the same procedure.

Does Park Avenue Stem Cell Use Any Embryonic Stem Cells?

No. Only adult mesenchymal stem cells are used. These cells are capable of forming bone, cartilage, fat, muscle, ligaments, blood vessels, and certain organs. Embryonic stem cells are associated with ethical considerations and limitations.

Does Park Avenue Stem Cell use stem cells from any other animal source or person?

No. Only a person’s own adult autologous cells are used. These are harvested from each individual and deployed back into their own body. There is no risk of contamination or risk of introduction of mammalian DNA into the treatments.

Why do some stem cell facilities around the world require days to weeks before removal of mesenchymal stem cells until reinsertion into the patient?

These facilities are obtaining stem cells from bone marrow or blood in relatively small quantities and they are then culturing (growing) the cells to create adequate quantities. Research seems to indicate that success of treatment is directly related to the quantity of cells injected. PASC uses adipose derived stem cells that are abundant naturally at approximately 2,500 times levels found in bone marrow (the most common source of mesenchymal stem cells). PASC uses technology that isolates adipose stem cells in vast numbers in a short time span so that prolonged culturing is unnecessary and cells can be deployed into a patient within 90 minutes of harvesting.

What claims are currently made by PASC about what stem cell therapy can do for you?

None. Our aim is to make cell based medicine available to patients who are interested and to provide ongoing research data under approved Institutional Review Board (IRB) validated studies. We will follow our stem cell treatment patients over their lifetimes. This will enable us to accumulate significant data about the various degenerative diseases we treat. Instead of providing simply anecdotal or testimonial information, our goal is to categorize the various conditions and follow the patient’s progress through various objective (e.g. x-ray evidence or video displays) and subjective (e.g. patient and/or doctor surveys) criteria. We are aware of a lot of stories about marked improvement of a variety of conditions, but we make no claims about the intended treatment. At some point, once adequate amounts of data are accumulated, it might be appropriate to submit the information to the FDA at which point an actual claim may be substantiated and recognized by the Agency. Still, these are your own cells and not “medicines” for sale. They are only being used in your own body. Most likely, no claim needs to be made; rather a statistical analysis of our findings would suffice to suggest whether treatments are truly and significantly effective. We also hope to submit our patient’s data to an approved International Registry (See ICSS Stem Cell Registry) further fostering large collections of data to help identify both positive and negative trends.

Is everyone a candidate?

No. Only certain medical problems are currently being treated at PASC. All patients need to be medically stable enough to have the treatment in our facility. There may be some exceptional conditions that may eventually be treated in hospitalized patients, but that remains for the future. Some patients may be declined due to the severity of their problem. Other patients may not have conditions appropriate to treat or may not be covered by our specialists or our protocols. A waiting list or outside referral (if we know of someone else treating such a problem) might be applicable in such cases.

Are any patients automatically excluded?

Yes. Patients with uncontrolled cancer are excluded. If you have an active infection anywhere in your body you must be treated first. Severely ill patients may require special consideration. Also, anyone with a bleeding disorder or who takes blood thinning medications requires special evaluation before consideration for stem cells.

Who decides who is eligible?

The specialist seeing you at PASC will make a determination based on your history and exam, studies, and current research findings. Any complex cases may be reviewed by our ethics advisory committee. Occasionally, we may seek opinions from thought leaders around the world.

Does a candidate have to participate in research to receive treatment at PASC?

No. Participation in any of our protocols is not mandatory and there are no incentives, financial or otherwise, to induce patients to enroll in our studies. However, PASC is dedicated to clinical research for the development of stem cell science. PASC is taking an active role in cutting edge clinical research in the new field of regenerative medicine. Research studies will be explained and privacy will be maintained. Formal future research studies will be regulated by an Institutional Review Board which is an authorized agency that promotes validity, transparency and protection of human study enrollees.

What is the cost of consultation and treatment?

There is no charge for a consultation. Unfortunately, insurance generally will not cover the actual cost of stem cell treatment in most cases since stem cell therapy is still considered experimental. The cost varies depending on the disease state being treated and which type of stem cell deployment is required.

What does the cost of procedure include?

Because of recent innovations in technology, PASC is able to provide outpatient stem cell treatment at a fraction of the cost of that seen in many overseas clinics. Our fees covers Stromal Vascular Fraction SVF harvesting, preparation, and deployment which may include the use of advanced interventional radiology and fluoroscopy techniques. Total costs will be determined after a medical evaluation.

Once a candidate is selected for treatment, how does PASC obtain a person’s stem cells?

Stem cells are harvested and deployed during the same procedure. Our patients undergo a minimally-invasive liposuction type of harvesting procedure by a surgeon in our specialized treatment facility in a Treatment Center closest to you. The harvesting procedure generally lasts a few minutes and can be done under local anesthesia. Stromal Vascular Fraction SVF which contains mesenchymal stem cells and growth factors is then processed from 2 ounces of fat using a closed sterile system to avoid contact with the environment. SVF is ready for deployment within 90 minutes or less.

How is Fat Obtained?

PASC patients have their fat (usually abdominal) harvested in our special sterile treatment facility under a local anesthetic. The fat removal procedure lasts approximately twenty minutes. Specially designed equipment is used to harvest the fat cells and less than 100cc of fat is required. Post operative discomfort is minimal and there is minimal restriction on activity.

How are the cells deployed into a patient?

Depending on the type of treatment required, stem cells can be injected through veins, arteries, into spinal fluid, subcutaneously, or directly into joints or organs. All of these are considered minimally invasive methods of introducing the stem cells. Stem cells injected intravenously are known to “seek out and find” (see photo) areas of tissue damage and migrate to that location thus potentially providing regenerative healing. Intravenously injected stem cells have been shown to have the capability of crossing the “blood-brain barrier” to enter the central nervous system and they can be identified in the patient’s body many months after deployment. Note yellow arrow showing the stem cells concentrated in the patient’s hand where he had a Dupytren’s contracture (Dupuytren’s contracture is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract).

How many injections are required for success?

Most patients, especially those with orthopedic conditions, require only one deployment. Certain types of degenerative conditions, particularly auto-immune disease, may respond best to a series of stem cell deployments. The number and necessity of any additional treatments would be decided on a case by case basis. Financial consideration is given in these instances.

Can I be expected to improve after stem cell treatment at Park Avenue Stem Cell?

Different conditions are treated in different ways and there are different degrees of success. If the goal is regeneration of joint cartilage, one may not see expected results until several months after treatment. Some patients may not experience significant improvement and others may see dramatic regeneration of damaged tissue or resolution of disease. Many of the disorders and problems that the physicians at PASC are treating represent pioneering work and there is a lack of data. FDA regulations prevent PASC from making any claims about expectations for success, however, if you are chosen for treatment, it will be explained that we believe stem cell therapy may be beneficial or in some cases that we are unsure and treatment would be considered investigational.

How long does it take to see improvement?

Stem cell therapy relies on the body’s own regenerative healing to occur. The regenerative process may take time, particularly with orthopedic patients, who may not see results for several months. In some diseases, more immediate responses are possible.

Why freeze cells today, can’t I just wait until I need them?

We believe your cells represent an important form of “bio-insurance.” Producing your cells after an “elective” mini-liposuction during a convenient time that you choose has several advantages. Not only can we store your own DNA now, but we should be able to soon culture your cells to increase the total quantity of stem cells, too.

On the serious side, if you have a heart attack or stroke or unexpected severe injury or illness you might not be in a situation that would permit elective liposuction. ,You may benefit from rapid deployment of your own stem cells which could be best achieved if they were readily available “on ice” and ready to be sent to your physicians.

Many sports injuries could be more rapidly repaired using your own stem cells. If athletes – professional, collegiate and even high school – that participated in sports known for contact injuries could harvest their cells during a convenient off-season period their cells would always be ready when needed.

The way we treat cancer is about to change in a revolutionary way and your stem cells may be an integral part of a cancer treatment. Cancer patients are often debilitated and might benefit from having access to healthy stem cells taken from their bodies before they contracted their disease. These stem cells may carry vital cancer killing agents directly into the tumor. Also, with new special blood testing that can detect cancer cells before they become clinically apparent (e.g. seen, felt, or detected on MRI or x-ray), it may also be possible for your cells to hunt down these cancer cells before you get sick.

Based on research being done now, healthy stem cells removed in your youth may play an important clinical role in longevity and wellness also. Your cells may be the key to the “fountain of youth.” Because your cells have the capacity to be replicated, by banking cells now, we can eventually set up the replication process so we can return many more of your own cells from time to time. In theory, by frequently providing you your own stem cells, they can be used to continually renew vital body parts as they naturally deteriorate from routine cell death. Imagine being able to maintain healthy heart and vital function with youthful stamina and strength well in your hundreds – we believe this is possible. We say “taking good care of your cells and being able to replace them” may be the key to longevity with good health and function. While allogenic (from other people) stem cells may one day be available, we’re committed to preserving your own DNA as well.

Additionally, if you suffer from a condition that requires multiple infusions of stem cells, it would be much easier to harvest more fat and thus cells at one sitting and simply receive the cells when necessary from time to time without going through a cell harvesting procedure (e.g. liposuction or bone marrow tap) each visit. The key to successful cell therapy in many cases is repeat treatments.

Finally, a lot of people want to get rid of undesired fat for appearance sake. That means that thousands of people every year end up throwing away their wonderful stem cells without even knowing it. We think this is a terrible waste and that patients should be routinely advised that they can freeze their cells to save the fat and stem cells as they choose.

Is it true that stem cells are healthier when one is younger?

Yes, younger cells are best. In general, cells in fat are much more durable and stable with age in comparison to bone marrow derived cells where the quantity of stem cells and proliferative potential (vitality) decreases every decade of life. However, even in fat derived cells, the quality of the stem cells does diminish gradually with age and the best cells are stored when you are younger but it’s never too late if you plan.

Is frozen SVF pure stem cells?

No. Your stem cells from fat tissue are frozen in the form of SVF which is derived from processing your fat. SVF is also known as Stromal Vascular Fraction. This is derived from the liposuction and digestion of the loose connective tissue that surrounds small blood vessels and fat. This connective tissue binds mesenchymal stem cells including cells that are destined to become blood vessels and fat but can be diverted for repair and regeneration of numerous tissues around the body including nerve, muscle, blood vessel, bone, and many more. In addition to these stem cells, there are abundant white blood cells, lymphocytes, immune cells, growth factors, and other cell types such as red blood cells, endothelial cells and epithelial cells.

At some point in the not too distant future, we will be able to “expand” (replicate multiple times) the stem cells in your SVF which makes them immortal and will provide an unlimited supply of healing cells. Once your SVF is “expanded,” only the stem cells will be replicated. These expanded stem cells will be frozen as pure cells instead of SVF.

How are my stem cells frozen?

Your fat will be converted into SVF which includes mesenchymal adult stem cells. The process will be performed in an FDA approved sterile lab where experts will bathe the SVF cells in a vital fluid that protects them during the freezing process. They are then stored at 190 degrees below zero. Twenty five 25cc of condensed fat can be converted into up to four aliquots of SVF which are individually frozen and available for 4 different treatments.

How are my stem cells thawed?

Under appropriate regulatory approval, your frozen SVF can be returned to your physician. Thawed SVF must be treated, washed and filtered to prepare it for deployment. This process requires special training and equipment which is now available at approved physician’s offices all over the United States. The thawing process is very important and many steps are taken to ensure that the cells are undamaged by their journey and are healthy and ready to work when you need them.

How do we know that the cells survive the freezing and thawing process?

As measured by the proliferative potential (time it takes for cell replication) and differentiation ability (ability to form different tissues) we provide evidence that shows the SVF can be frozen and thawed for use while maintaining its vitality. Validation studies confirm that cells that are properly frozen and thawed have the same viability as fresh tissue.

What is SVF being used for today?

There are numerous uses for SVF. SVF is currently being studied as a potential treatment for a variety of degenerative and inflammatory conditions such as heart disease, COPD and emphysema, critical limb ischemia, many degenerative diseases of the eye, Peyronies disease and interstitial cystitis, lichen sclerosis, and orthopedic conditions such as osteoarthritis, chronic and acute muscle and tendon injuries and even to help speed up and better mend fractures and other orthopedic surgical procedures. It is being used and will find more uses for a large variety of neurological conditions including stroke, concussion, traumatic brain injuries of all kinds, muscular dystrophy, multiple sclerosis, Alzheimer’s, Parkinson’s, and others. SVF is also used in auto-immune and even in some rare congenital disorders. Studies are also ongoing to use SVF to help deliver cancer killing agents directly into the tumor.

Does the cell harvesting hurt?

Mini-lipoharvesting can be performed under local anesthesia through a tiny 2mm puncture in a very short time. This generally is completed within 10 – 15 minutes. Patients report minimal discomfort and can be back to work right away. Patients can also save some of the fat from elective cosmetic procedures by telling their surgeon ahead of time to contact Cells On Ice and they will be provided with a kit for sending some fat to our facility. Sadly, much fat is simply “thrown away” after these liposuctions and patients do not realize that they are disposing of their own “liquid biologic gold.”

What are the risks of receiving my own mesenchymal stem cells?

Minimal. Excellent safety data has been shown with the use of autologous cell therapies (1). There have been more than 17,000 scientific articles involving 2,724 cell therapy clinical trials have been published since 2000. (2). These results include 323,000 patients receiving more than 675,000 cell deployments.. The treatments were very safe and often highly effective in the mitigation of various degenerative conditions. (1,2,3). The Cell Surgical network and its affiliate center Park Avenue Stem Cell Treatment Center has performed over 2000 IRB approved procedures for the deployment of SVF containing autologous stem cells for various degenerative conditions showing extremely good safety data.

What tests do I need prior to cryo-preserving my stem cells?

Certain basic laboratory tests are required before the Cells On Ice cryobank can accept any human tissue in order to eradicate the chance of spread of communicable disease. These simple blood tests include: syphilis, HIV, and Hepatitis.

Where will my cells be kept?

Your cells will be in large tanks filled with liquid nitrogen in a secure main location in New Jersey. This sterile facility was established in 2008 for the sole purpose of storing and eventually replicating autologous (i.e. your own) adult stem cells. Many failsafe systems are in place to protect your cells from unexpected events such as power loss or natural disaster.

How long can my cells stay in cryogenic state?

Indefinitely. The freezing process is designed so that cells frozen for long periods can have excellent viability. You can even make arrangements to will them to others including family members with your genetics or even other people who might benefit from cell therapy but are unable to have their own cells available. Cryobiology has demonstrated that frozen cells can remain viable for many decades.

How can I be sure my cells cannot be mixed up with someone else’s?

Multiple overlapping systems are in place to protect labelling and the “chain of custody” which means that your stem cells are identified strictly as your own and cannot be mixed up with someone else’s cells either in storage or in transit.

What if I need my cells for multiple repeat treatments?

We are now able to freeze your stem cells in the form of SVF in as many as 4 small vials that can be individually thawed for individual serial treatments. By harvesting extra fat, should it be available, one could provide multiple additional vials for multiple periodic deployments. Once we are able to expand cells, the supply will be essentially unlimited.

Can we freeze fat also?

Yes, we are also able to freeze fat before it is made into SVF. This takes up more room but should excess fat tissue be available by storing it you maintain an excellent source of tissue that can be very effective for cosmetic procedures like facial fat grafting, breast augmentation or repair of various defects that may occur with age, trauma or disease.

Can we freeze stem cells from bone marrow or umbilical cord?

Yes, in some cases that is possible, but will require special arrangements. Please call 855-204-0302 to discuss options.

Is it affordable?

We believe this may be the best health insurance you could ever purchase. While there will always be diseases that require medical and surgical intervention, eventually, all conditions will require replacement or supplementation with new cells (i.e. replacement parts). To store your SVF as Bio-insurance, the general cost is $2,500 and that include the first year’s storage fee. After that, there will be an annual storage fee of $240/year.

If you have very average health insurance for yourself only, it’s probably costing over $500/month or $6,000 / year. This may end up being one of the cheapest and most valuable insurance policies you may possess.

I have cord blood from when I was a baby, how is this different?

Cord blood technically contains some stem cells in quite low quantities and these may not be sufficient for your future medical needs.

I may have a family member who becomes ill. Who else can use my cells?

Under special circumstances, first degree relatives may be able to use your cells. Special blood screening would be necessary as well as regulatory approval.

Are stem cells being used for cancer treatment?

Research is actively ongoing to use stem cells to help advance cancer therapies. Stem cells have a unique ability to detect abnormal tissue and can play an active role in the destruction of cancer cells by bringing cancer killing agents directly to the cancerous tissue in a targeted fashion. Stem cells can also play a vital role in the mitigation of cellular damage to living tissue that resulted from the administration of chemotherapy or radiation therapy in an attempt to kill tumors. Much of the original stem cell research was done to show that stem cells were indeed essential for treating radiation damage.

How does the FDA regulate cryo preservation technology?

The FDA registers and may inspect cryo-preservation facilities. The cryopreservation of stem cells is highly regulated to protect patients from the transmission of infectious disease. Your cells will be preserved in a bank that has the highest standards.

 



“The Cell Surgical Network and its affiliate treatment centers are not offering stem cell therapy as a cure for any condition, disease, or injury. No statements or implied treatments on this website have been evaluated or approved by the FDA. This website contains no medical advice. All statements and opinions provided by this website are provided for educational and informational purposes only and we do not diagnose or treat via this website or via telephone. The Cell Surgical Network and its affiliate treatment centers are offering patient funded research to provide individual patients with Stromal Vascular Fraction that contains their own autologous stem cells and growth factors and the treatment centers provide surgical procedures only and are not involved in the use or manufacture of any investigational drugs.


The Cell Surgical network does not claim that any applications, or potential applications, using autologous stem cells are approved by the FDA, or are even effective. We do not claim that these treatments work for any listed nor unlisted condition, intended or implied. It’s important for potential patients to do their own research based on the options that we present so that one can make an informed decision. Any decision to participate in our patient funded experimental protocols is completely voluntary.


ATTENTION: If you have ANY concern with stromal vascular fraction, any of our products, methods, website, or technique and think we may be violating any U.S. law, please contact us so that we can investigate the matter or concern immediately.


Disclaimer:
**Results of these treatments vary from individual to individual and it is not possible to predict or guarantee the outcome of any medical procedure.

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