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Category Archives: BioMed Central

RNA-binding proteins in mouse male germline stem cells: a mammalian perspective

Posted on March 13, 2016

Abstract Adult stem cells that reside in particular types of tissues are responsible for tissue homeostasis and regeneration. Cellular functions of adult stem cells are intricately...

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Wnt/?-catenin signaling in heart regeneration

Posted on March 13, 2016

Abstract The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost...

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The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis

Posted on March 13, 2016

 Abstract Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is characterized by the selective degeneration of upper motor neurons and lower spinal motor neurons,...

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Stem cell therapy for amyotrophic lateral sclerosis

Posted on March 13, 2016

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS,...

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Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

Posted on March 13, 2016

Background Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery...

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